| Citation |
|---|
| Tyson JJ, (1991) . Modeling the cell division cycle: cdc2 and cyclin interactions. PNAS, 88: 7328-7332. http://www.pnas.org/cgi/content/abstract/88/16/7328 |
| Description |
|---|
| A model of the cell cycle based on the interactions between cdc2 and cyclin. The model has six dynamic variables: C2 (cdc2); CP (cdc2-P complex); pM (P- cyclin-cdc2-P complex); M (active MPF, P-cyclin- cdc2 complex); Y (cyclin); and YP (cyclin-P) . Total cyclin concentration (YT) is the sum YT=Y+YP+pM+M4 |
| Rate constant | Reaction |
|---|---|
| k1aa = 0.015 | EmptySet -> Y |
| k2 = 0 | Y -> EmptySet |
| k3 = 200 | CP + Y -> pM |
| k4prime + k4*M[t]^2 | pM -> M |
| k5notP = 0 | M -> pM |
| k6 = 1 | M -> C2 + YP |
| k7 = 0.6 | YP -> EmptySet |
| k8notP = 1000000 | C2 -> CP |
| k9 = 1000 | CP -> C2 |
| Variable | IC | ODE |
|---|---|---|
| C2 | 0 | C2'[t] == -(k8notP*C2[t]) + k9*CP[t] + k6*M[t] |
| CP | 1 | CP'[t] == k8notP*C2[t] - k9*CP[t] - k3*CP[t]* Y[t] |
| M | 0 | M'[t] == -(k5notP*M[t]) - k6*M[t] + ( k4prime + k4*M[t]^2)*pM[t] |
| pM | 0.3 | pM'[t] == k5notP*M[t] - (k4prime + k4*M[t]^2)* pM[t] + k3*CP[t]*Y[t] |
| Y | 0 | Y'[t] == k1aa - k2*Y[t] - k3*CP[t]*Y[t] |
| YP | 0 | YP'[t] == k6*M[t] - k7*YP[t] |